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CBDA vs. CBD: What’s the Difference + 10 Benefits of Each

Cannabidiol (CBD) and cannabidiol acid (CBDA) are two different forms of the cannabis compound. CBD is well-known for its therapeutic benefits, while CBDA has only recently been studied for its potential effects. This article will explore the differences between CBD and CBDA, as well as the potential benefits of each.


Cannabidiol Acid (CBDA)

Definition and Overview

CBDA, or Cannabidiolic Acid, is a naturally-occurring cannabinoid found in the raw form of cannabis plants and hemp. It's structurally similar to CBD but with some key differences that give it unique therapeutic benefits that are still being researched today. Some potential uses include anti-inflammatory and anti-anxiety effects and relief from nausea, vomiting, and convulsions. CBDA can also act as an antiemetic, reducing or preventing nausea caused by chemotherapy treatments.


The Current Research on CBDA

CBDA has been a topic of research for over ten years now. An early 2008 study looked into the potential of CBDA as an anti-inflammatory and found that its molecular structure was similar to common non-steroidal anti-inflammatory drugs (NSAIDs). It was also discovered that CBDA inhibits COX-2 receptors, giving it promise as an effective anti-inflammatory agent.

Similarly, one reason why CBDA is effective against nausea is its affinity for 5-HT receptors, which is 100 times stronger than CBD. Since CBDA has better bioavailability, it's easier for the body to metabolize this compound; thus giving it faster results than other compounds that rely only on CBD.

Perhaps even more promising is its ability to potentially fight depression due to its effects on 5-HT receptors, which are similar to those seen in Selective Serotonin Reuptake Inhibitor (SSRI) medications prescribed by doctors.

Despite the fact that most CBDA studies to date are preclinical, medical cannabis companies such as British-based GW Pharmaceuticals are working to change this. In 2018, their pharmaceutical-grade CBD oil Epidiolex became the first cannabis-derived prescription drug approved by the FDA. The FDA further demanded research on CBDA's precursor be conducted; results showed CBDA to be an even more effective seizure treatment.

GW Pharmaceuticals has also filed two patents related to medical uses of CBDA - one for inflammatory skin diseases and another for cancer treatments. Although the research conducted so far has been limited to isolated cells, initial findings suggest that CBDA may halt the growth of a particularly aggressive form of breast cancer cells known as MDA-MB-231.

10 Potential Benefits

1. Anti-Inflammatory

CBDA may help reduce inflammation and swelling caused by certain medical conditions like arthritis, joint pain, and other inflammatory diseases. Research conducted in cell cultures has demonstrated promising anti-inflammatory properties of CBDa. A 2008 study published in Drug Metabolism and Disposition found that CBDa is a selective COX-2 inhibitor.

The COX-2 enzyme is responsible for producing pro-inflammatory compounds called prostaglandins, which are common targets of non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and aspirin. Inflammation is a natural immune response to stress, injury, and illness; however, chronic inflammation can be detrimental to health and result in painful conditions like arthritis.

The research from 2008 found that CBDa selectively blocks the activity of the COX-2 enzyme, diminishing its ability to synthesize pro-inflammatory compounds. This makes CBDa more effective than its counterpart - tetrahydrocannabinolic acid (THCA).

2. Cancer-fighting potential

Some studies indicate that CBDA may be able to fight certain types of cancer. Studies from 2012 have identified the potential for CBDa to hinder migration in breast cancer cells grown outside of the body, indicating a positive effect against an aggressive form of breast cancer. If successful, a therapy that inhibits the migration of cancer cells would be able to prevent its spread to other body parts.

Cell culture research conducted in 2014 further supported these claims, finding that treatment with CBDa could alter gene expression associated with metastasized breast cancer and decrease levels of COX-2, which is known to enhance tumor cell migration.

3. Antiemetic

It can help reduce or prevent nausea caused by chemotherapy treatments and general nausea from other medical conditions. In addition, research conducted on rodents suggests that raw cannabis juice may have the potential as an anti-nausea remedy. A 2012 study published in the British Journal of Pharmacology found that CBDa reduced nausea responses in rodents and suppressed vomiting in shrews; interestingly, CBDa was more effective at calming an upset stomach than activated CBD.

4. Anti-Anxiety

It has been shown to reduce feelings of anxiousness and stress because of its calming effects.

5. Pain relief

CBDA may help reduce pain caused by neuropathy and fibromyalgia.

6. Anti-seizure

Studies suggest that it may reduce the frequency and intensity of seizures.


7. Cardiovascular health

It may help improve cardiovascular health by helping regulate blood pressure and cholesterol levels.

8. Antioxidant activity

CBDA has been shown to contain antioxidant properties which protect against cell damage caused by free radicals in the body.

9. Appetite stimulation

Studies suggest that it may help stimulate appetite in people with trouble eating.

10. Nausea relief

CBDA has been shown to have antiemetic effects, which means it can help relieve nausea or vomiting caused by chemotherapy treatments.

Delivery Methods for Consuming CBDA

CBDA can be ingested orally in the form of capsules or tinctures. You can also apply it on the surface of the skin, and be used topically as a balm or cream and inhaled through vaping.

Considerations when Purchasing CBDA Products

When purchasing any CBDA product, it is vital to ensure that you buy from a reputable source, such as Let it Grow. They are a trustworthy brand because all of their products are third-party tested and have the appropriate labeling to know precisely what you're getting. Additionally, if you plan on using CBDA topically or inhaling it through vaping, research the potential risks of these methods before doing so.

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FAQs about CBDA

Q: Is CBDA more potent than CBD?

Yes, it is believed that CBDA is more potent than CBD as an antioxidant and anti-inflammatory agent.

Q: How can I consume CBDA?

CBDA can be consumed in a variety of ways, including through edibles, tinctures, capsules, and topical applications. However, it is important to remember that there are potential risks associated with some methods, such as vaping.

Q: Is CBDA legal?

The legality of CBDA depends on where you live. In some countries, it is completely legal to purchase and consume, while in others, there are restrictions or even bans on its usage. It is essential to stay updated with your local laws regarding CBD products before making any purchases.

Q: Are there any side effects associated with CBDA?

Some users have reported feeling more relaxed after consuming CBDA, but to date, there are no known serious side effects associated with its use. However, it is always important to consult a medical or health professional before adding new supplements to your routine. Additionally, if you plan on vaping or using topical CBDA, research the potential risks associated with these methods. If you have hesitations, it is best to consult your doctor before use.

Q: What is Decarboxylation?

Decarboxylation is the process of heating CBDA to convert it into CBD, making it possible for the body to absorb and use it. This conversion can be done through a variety of methods, such as smoking or baking it in an oven at a certain temperature.

Cannabidiol (CBD)

CBD, or Cannabidiol, is a naturally-occurring chemical compound that can be extracted from the cannabis plant. It is then processed into an oil form for easier consumption. Unlike its cousin THC (tetrahydrocannabinol), known for its psychoactive properties, CBD does not produce any "high" or intoxication when consumed. Instead, it has been researched to have potential therapeutic benefits in treating certain medical conditions.

Definition and Overview

Cannabidiol (CBD) is a naturally-occurring chemical compound that can be extracted from the cannabis plant. It is then processed into an oil form for easier consumption. Unlike its cousin THC (tetrahydrocannabinol), known for its psychoactive properties, CBD does not produce any "high" or intoxication when consumed. Instead, it has been researched to have potential therapeutic benefits in treating certain medical conditions, such as chronic pain and inflammation, anxiety, and trouble sleeping. In addition to these potential health benefits, CBD is also being explored for its potential anti-inflammatory, anti-anxiety, and analgesic effects.


The Current Research on CBD

Researchers from the University of Chicago have identified that CBD, a product derived from the cannabis plant, may be able to inhibit SARS-CoV-2 infection. Published in Science Advances on January 20th, 2022, the study found that medical records of patients taking an FDA-approved treatment for epilepsy had a significant negative correlation with SARS-CoV-2 positive tests. Clinical trials must be conducted to determine whether specially crafted and highly pure CBD doses can be used to prevent or treat COVID-19; however, this research does not suggest commercially available products with varying potency and quality that can ward off the virus. During the ongoing pandemic, scientists seek new therapies for those infected with coronavirus variants which don't have access to vaccines, especially given the rise of breakthrough infections.